A doctor charged with giving Matthew Perry ketamine in the weeks leading up to the "Friends" star's overdose death is expected to plead guilty Wednesday.

Dr. Salvador Plasencia would be the fourth of five people charged in connection with Perry's death to plead guilty.

President Donald Trump said he has reached a trade agreement with Philippine leader Ferdinand Marcos Jr., following a meeting Tuesday at the White House, that will see the U.S. slightly drop its tariff rate for the Philippines without paying import taxes for what it sells there.

Trump revealed the broad terms of the agreement on his social media network and said the U.S. and the Philippines would work together militarily. The announcement of a loose framework of a deal comes as the two countries are seeking closer security and economic ties in the face of shifting geopolitics in the Indo-Pacific region.

U.S. President Donald Trump has announced trade deals with Japan and a handful of other Asian countries that will relieve some pressure on companies and consumers from sharply higher tariffs on their exports to the United States.

A deal with China is under negotiation, with U.S. Treasury Secretary Scott Bessent saying an Aug. 12 deadline might be postponed again to allow more time for talks.

Global shares rallied on Wednesday, with Tokyo's benchmark Nikkei 225 index gaining 3.5% after Japan and the U.S. announced a deal on President Donald Trump's tariffs.

France's CAC 40 added 1.4% in early trading to 7,854.75, while Germany's DAX gained 0.9% to 24,260.62. Britain's FTSE 100 rose 0.6% to 9,075.46. The future for the S&P 500 gained 0.4% while that for the Dow Jones Industrial Average was up 0.5%.

Japan's far-right populist Sanseito party was one of the biggest winners in the weekend's upper house election, attracting many voters with its "Japanese First" platform that included calling for tougher restrictions on foreigners and the curtailment of gender equality and diversity policies.

Sanseito added 14 seats in Sunday's vote to the one seat already held by its leader in the 248-member upper house, the less powerful of Japan's two-chamber parliament.

The UN's highest court is handing down a historic opinion on climate change Wednesday, a decision that could set a legal benchmark for action around the globe to the climate crisis.

After years of lobbying by vulnerable island nations who fear they could disappear under rising sea waters, the U.N. General Assembly asked the International Court of Justice in 2023 for an advisory opinion, a non-binding but important basis for international obligations.

Ukrainian activists called for more protests against a law they say weakens the country's anti-corruption bodies. The legislation has also drawn rebukes from European Union officials and international rights groups.

Thousands of people gathered in the capital and other cities across Ukraine on Tuesday evening to urge President Volodymyr Zelensky to veto a controversial bill passed by Ukraine's Parliament earlier that day. After Zelensky approved it, activists called on social media for another demonstration in the center of Kyiv at 8 p.m. Wednesday.

President Donald Trump on Tuesday said a trip to China might be "not too distant," raising prospects that the leaders of the world's two largest economies may meet soon to help reset relations after moving to climb down from a trade war.

Trump made the remarks while hosting Philippine President Ferdinand Marcos Jr. at the White House, where he praised the "fantastic military relationship" with Manila as the U.S. looks to counter China's influence in the Indo-Pacific region.

President Donald Trump announced a trade framework with Japan on Tuesday, placing a 15% tax on goods imported from that nation.

"This Deal will create Hundreds of Thousands of Jobs — There has never been anything like it," Trump posted on Truth Social, adding that the United States "will continue to always have a great relationship with the Country of Japan."

The U.N. Security Council urged the 193 United Nations member nations on Tuesday to use all possible means to settle disputes peacefully. The U.N. chief said that is needed now more than ever as he pointed to "the horror show in Gaza" and conflicts in Ukraine, Sudan, Haiti and Myanmar.

The vote was unanimous on a Pakistan-drafted resolution in the 15-member council.