American and Iranian officials were holding face-to-face talks in Pakistan on Saturday, the most significant since the 1979 Islamic revolution as the foes try to end a war that plunged the Middle East into violence and rocked the world economy.

Ali Akbar Velayati, an adviser to Iran's supreme leader, said on X that Lebanese Prime Minister Nawaf Salam "should know that ignoring the unique role of the resistance and the heroic Hezbollah will expose Lebanon to irreparable security risks."

"Lebanon's stability rests exclusively on cohesion between the government and the resistance," he said.

The Lebanese National News Agency reported multiple Israeli strikes early Saturday in southern Lebanon, killing at least three people.

Hezbollah lawmaker Hassan Fadlallah on Saturday reiterated his group's rejection of direct negotiations between Israel and Lebanon, where authorities reported 10 people killed in Israeli attacks in the south.

Israel said Friday it will not discuss a ceasefire with Hezbollah when it holds talks with Lebanon's government next week in Washington.

U.S. President Donald Trump vowed Friday to have the Strait of Hormuz open "with or without" Iran's cooperation, and said his top priority in peace talks was to ensure Tehran can't have a nuclear weapon.

U.S. Vice President JD Vance arrived in Islamabad on Saturday for talks with Iran that the Pakistani premier hosting the warring sides called a "make or break" effort to permanently halt weeks of fighting in the Middle East.

An Israeli strike, one of multiple on the southern Lebanese city of Nabatiyeh on Friday, killed 13 State Security personnel, the agency said, as Lebanon prepared to start ceasefire talks with Israel.

The Israeli military said Friday that airstrikes it carried out in Lebanon two days earlier killed more than 180 Hezbollah militants.

Iran demanded a truce in Lebanon and the release of its blocked assets on Friday as U.S. Vice President JD Vance warned Tehran not to "play" Washington, casting doubt on planned ceasefire talks in Pakistan.